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And in August, Pfizer ended development of its third and final oral GLP-1 candidate, PF-06954522, after a review of its phase 1 clinical performance and the overall GLP-1 landscape

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Equipment needed: Chest strap heart rate monitor (more accurate than wrist-based devices) Heart rate variability (HRV) app Blood pressure cuff Spreadsheet or tracking app Daily measurements: Morning resting heart rate (before getting up) Morning HRV (using chest strap, 5-minute measurement) Blood pressure (morning, before caffeine) What to track: 7-day rolling average of resting HR (smooths daily variation) HRV trend (declining HRV indicates autonomic stress) Blood pressure trend (should improve or stay stable) Subjective cardiac awareness (scale of 0-5) This level of monitoring is not necessary for most people, but for those who want complete data, it provides early warning of adverse trends and concrete evidence of cardiovascular adaptation over time

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