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However, this solution may not last long
A subsequent pooled analysis confirmed significantly greater proportions of patients achieving 5%, 10%, and 15% weight loss compared to placebo, along with pronounced improvements in fasting glucose and BMI (141) These strong Phase II results underpinned the Phase III ACHIEVE-1 trial, which demonstrated dose-dependent HbA 1 c reductions of ~1.31.6% and 7.9% weight loss at 40 weeks, supporting the feasibility of oral GLP-1 therapy as a non-injectable alternative (143)
Others describe anxiety or mood changes, particularly early in treatment
People mention nausea, constipation, diarrhea, abdominal cramping, reflux, bloating, vomiting, and sulfur-smelling burps
Eng et al., J Biol Chem, 1992 Parkes et al., Diabetes Care, 2013 #GLP1 #DrugDiscovery #FromBenchToBedside #NephMadness #MedicalEducation #Endocrinology #Nephrology To view or add a comment, sign in More Relevant Posts Medicos quick Platelets MCQ
doi: 10.1210/endo.136.8.7628397 52 VilsbllTAgersHLauritsenTDeaconCFAaboeKMadsbadSet al
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