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Elevated NNMT activitycommon in obesity and metabolic syndromedepletes NAD+ reserves by shunting nicotinamide into an excretory pathway rather than salvaging it for NAD+ biosynthesis

Your body removes waste products through your: Stool Urine Sweat Three of the organs and systems that are involved in detoxification, among others, are the: Liver Interstitium- a network of connective tissue and fluid-filled compartments found throughout your body Immune system These organs and systems form part of the Detoxification circuit in the NeuroEndoMetabolic (NEM) Stress Response System