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Persistent activation and accumulation of myofibroblasts without resolution of the reparative response underlies the progressive nature of fibrotic reactions in injured tissue [5]

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The anionic nature of superoxide and the fact that it is mostly produced in the mitochondrial matrix determine that the bulk of antioxidant defenses to neutralize superoxide and other ROS reside in the matrix

If treatment is not appropriate that day, we will say so and recommend a safer next step

Severe, acute reactions, such as: Salicylate overdose, which can cause metabolic derangement, fever, and hyperventilation