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Causes include PCOS, thyroid issues, or extreme weight changes

it could be reduced within the ER by a glutathione reductase, it could be transported to the cytosol for reduction, or it could be secreted from the cell

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Furthermore, even slightly elevated levels of Hcy (10 mol/L) can effectively stimulate the accumulation of MCP-1 and IL-8 in the injured artery wall, thereby promoting macrophage-mediated inflammation and atherosclerosis (217, 218)

These alterations are common features of both T1DM and T2DM