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This is allowed by the Otopetrin-1 (OTOP1) channel and the expression of the polycistin-2-like 1 (Pkd2l1) gene, which allows proton entry, and generating lower intracellular pH (around 3.9) to block K+ channels and depolarizing the TRCs (5355)

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The FDA subsequently worked with manufacturers to update product labeling, with updates rolling out through early 2026

The resulting fatty streaks evolve into advanced atherosclerotic plaques characterized by a lipid-rich necrotic core covered by a fibrous cap, which may rupture and cause catastrophic thrombotic events [1]