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Colson PH, Virsolvy A, Gaudard P et al (2016) Terlipressin, a vasoactive prodrug recommended in hepatorenal syndrome, is an agonist of human V1, V2 and V1B receptors: implications for its safety profile

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This trial, while not showing superiority of JTA-004 over placebo in the overall population, provides highly valuable insights into clinical trial design, placebo responses, and the potential need for better patient stratification in osteoarthritis research

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In vivo, apigenin treatment prevented infiltration and degranulation of mast cells, while suppressing IL-31 in the skin [134]