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Theres no standard for microdosing, says Alexandra Sowa, MD, founder of SoWell

But some doctors are skeptical, calling it experimental. The practice has gotten celebrity endorsement

Here's what we learned about five claims you might be hearing about microdosing GLP-1s: Myth #1: Microdoses Are Simply Smaller Doses of FDA-Approved GLP-1 Drugs FDA-approved GLP-1 medications come in prepackaged and prefilled syringes each syringe contains one prescribed dose

GLP-1 and GIP are incretin hormones that stimulate insulin secretion after an oral glucose load by binding GLP-1R, but both are rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4)

Some people even buy raw peptide powder and attempt to mix their own injections at home, a practice thats both illegal and unsafe

This notion is speculative at present, as no change in cognition was observed in one small RCT of exenatide in schizophrenia 140 , while a positive cognitive effect of liraglutide was only seen in an even smaller non-randomized open-label investigation of people with either depressive or bipolar disorders 178,179