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According to Celltrion, Steqeyma was approved based in part on the findings of a Phase III study in plaque psoriasis, which demonstrated that the biosimilar had no clinically meaningful differences versus Stelara in terms of efficacy or safety

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In rodents and in humans genetic evidence demonstrates that the loss of SIM1 causes hyperphagic obesity in addition to causing resistance to the anorectic effects of melanocortins [68,69]

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