As noted previously, currently we do not have any large clinical trials for the treatment of HF or CKD in patients with or without T2D using GLP-1RA
As of 2024, three GLP1 agonists have been approved for weight loss
In a rodent model, a novel GLP-1R/GIPR/GCGR triple agonist, SAR441255, has been shown to promote weight loss and the maintenance of healthy blood glucose levels and is superior to the GLP-1R/GCGR dual agonist (Saxena et al., 2023)
C.MooreF
Tropifexor and alderfermin are well tolerated (10,11,14), but RCTs showing efficacy on clinically relevant parameters (stool consistency, bowel movement frequency, and urgency) are still lacking
Neither hormone alone produces what you see with dual agonism