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Briefly, recombinant PDI protein (0.4 M) was incubated with indicated compounds at 37 C for 1 h in sodium phosphate buffer (100 mM sodium phosphate, 2 mM EDTA and 8 M DTT, pH 7.0)

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VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair

5-Amino-1MQ possesses a well-characterized pharmacological profile and high selectivity for NNMT, making it a valuable reference compound for studies involving NNMT enzyme biology, methyltransferase pathway regulation, structure-activity relationships, and inhibitor-target interactions

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