Peptides occupy a central position in AD pathobiology: pathogenic species such as A oligomers and tau-derived fragments drive synaptic failure, mitochondrial dysfunction, and neuroinflammation, whereas several endogenous neuropeptides exert compensatory neuroprotective, trophic, or homeostatic effects
10.3390/antiox11071374 100 WagnerJ.ParkL
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In patients with type 2 diabetes at high cardiovascular risk, semaglutide demonstrated significantly lower rates of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke compared to placebo, establishing the noninferiority of semaglutide
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doi: 10.1111/j.1468-2982.2009.01890.x 22