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IGF-1 DES is better suited for studying rapid, acute IGF-1 receptor signaling dynamics

This modification enhances NNTs affinity for its substrate NADP+, promoting NADPH synthesis, maintaining ironsulfur cluster homeostasis, lowering intracellular ferrous iron levels and lipid peroxidation, and thereby protecting tumor cells from ferroptosis (118)

The CARS level correlates positively with PD-L1 expression and may induce the trans-sulfur pathway, leading to cysteine deprivation and ferroptosis inhibition (103)

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Based on the target prediction analysis, they found that miR-657 indeed bound to IGF-1R 3UTR and miR-675 overexpression reduced the cell proliferation in embryonic and extra-embryonic cell lines, suggesting that miR-675 is involved in the H19 -mediated developmental control by targeting IGF-1R

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