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Studies have shown that X-ray irradiation reduces KGN cells viability, alters mitochondrial morphology, induces intracellular iron accumulation, and triggers lipid peroxidation, ultimately leading to ferroptosis (Zhao et al., 2023)

Additionally, several drugs can be involved, such as thiazide and loop diuretics (which increase urinary excretion) and antiacid drugs (PPIs, H2 receptor blockers)