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Auranofin shows an additive effect with COJEC chemotherapy Because the antagonism observed between RSL3 and COJEC appears to be mediated by GPX4 upregulation, we decided to test COJEC in combination with a ferroptosis-inducing agent with a different MOA, the TrxR inhibitor Auranofin

76 In addition, we will monitor his fibrinogen level and cut back on the number of TPE sessions if it drops below the lower average level of 1.5 g/L 77 to avoid the risk of excessive bleeding

If reconstituting with 2mL total, you will perform this process twice using 1mL per draw

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PMID 19891557