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Jensterle M, Kravos NA, Goricar K, Janez A (2017) Short-term effectiveness of low dose liraglutide in combination with metformin versus high dose liraglutide alone in treatment of obese PCOS: randomized trial

Tirzepatide (sold as Zepbound for weight loss) targets two of the three receptors that retatrutide hits and produces about 22.5% body weight loss

The company indicates that GLP-1 therapy may be HSA/FSA-eligible, but you should verify eligibility with your specific plan administrator

GLP-1 suppresses gastrointestinal motility and inhibits the migrating motor complex in healthy subjects and patients with irritable bowel syndrome

The trade-offs: higher cost, less dose flexibility, and dependence on manufacturer supply

doi: 10.1177/2042018820938305 198 Torres FernandezEDHuffmanAMSyedMRomeroDGYanes CardozoLL