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During this initial adjustment period, your body begins responding to the dual action of GLP-1 and GIP receptors, which work together to: Increase insulin when blood sugar is high Reduce appetite and cravings Slow digestion to help you feel full longer By weeks 4 to 6, many individuals lose 5 to 10 pounds as appetite stabilizes and metabolism becomes more efficient

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Incretins are gut hormones that amplify nutrient-induced insulin secretion in response to meal intake