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A 2023 study revealed that HSV-1 infection enhances the ubiquitination and degradation of NRF2 by the E3 ubiquitin ligase Keap1, disrupting cellular redox homeostasis and promoting ferroptosis in the mouse central nervous system

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Over-the-counter ibuprofen (200 mg) used occasionally for headaches or minor aches is generally safer than prescription-strength NSAIDs (600-800 mg) taken daily