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Toxicity is extremely rare, even with high doses

Everything you put in your body carries risk

Morphologically, no significant abnormalities were seen in the testes and spermatozoa of mice after SNGPX4 KO ( 2.5 GPX5 Glutathione peroxidase 5 (GPX5), an epididymis-specifically expressed selenium-free antioxidant enzyme, was first isolated and identified in the epididymal tissues of mice (Taylor et al., 2013)

Milk thistle also has a strong body of evidence for mechanisms by which it protects the liver against toxins as well as for its ability to therapeutically assist in chronic liver diseases (11)

doi: 10.1038/s41436-020-00990-1 65

A lot of supplements are overpriced for what they deliver, to be honest with you, says Dr