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Changing patterns in BTMs and BMD are similar to those found in calorie restriction interventions: CTX levels increased to a greater extent compared to those of PINP, and total hip BMD decreased to a greater extent compared to lumbar spine BMD [35, 36]

10.2337/diabetes.49.4.611 125 WajchenbergB

Consensus of Chinese experts on oral hypoglycemic drugs combined with initial insulin in the treatment of type 2 diabetes mellitus

Drug Targets 8 , 325331 (2007)

However, prolonged CR may diminish turnover in this compartment, occasionally yielding modest gains in trabecular indices as seen in female C57BL6J mice undergoing 30% CR during their vulverable period of accelerated bone resorption (i.e., between 8 and 16 weeks)

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