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One potential reason leptin has not panned out as a therapy on its own is a phenomenon known as leptin resistance. Thats when the body becomes desensitized to the hormone at higher levels, causing a person to feel hungry and eat more even though they have sufficient body fat

This kind of enteric-triggered release protects acid-labile compounds through the stomach and targets their release to intestinal absorption sites

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Sip water throughout the day and, if you find yourself overeating at mealtimes, try a glass of water 30 minutes before eating