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Developed to block the aromatase enzyme crucial for the estrogen biosynthesis pathway, particularly in adipose tissue post-menopause, Letrozole significantly reduces estrogen levels

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[1] Sequence studies have shown the protein to be similar both to alpha toxin from Clostridium perfringens and Clostridium bifermentans , a phospholipase C involved in haemolysis and cell rupture, [2] and to lecithinase from Listeria monocytogenes , which aids cell-to-cell spread by breaking down the 2-membrane vacuoles that surround the bacterium during transfer