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This complementary effect means men often achieve superior body composition outcomes compared to either therapy alone

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Weight loss can enhance insulin sensitivity and improve glycemic control in individuals with diabetes, reducing the need for higher doses of medication and potentially leading to diabetes remission in some cases

A 2025 clinical study in women with PCOS and obesity (n=56) found tirzepatide led to significant weight reduction (mean 9.54%) and improvement in menstrual regularity: irregular cycles decreased from 85.7% before treatment to 32.1% after

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