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Abstract Traditionally, Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs), a pivotal class of drug, mimics the actions of endogenous Glucagon-like peptide-1, which have been found to be remarkable in the treatment of type 2 diabetes alongside other comorbidities

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In fact, some early studies and patient reports indicate bloating and abdominal discomfort improve on GLP-1 therapy, likely due to the slowed, more gradual digestive process

In addition, it also enhances the pancreatic and duodenal homeobox gene-1 (PDX-1) transcription mediator expression, which further regulates the bio-synthesis of insulin, glucose transporter 2 , and differentiation of beta cells

However, these are not instant solutions