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These stromal fibroblasts, which interact with cancer cells, have increased levels of brain-derived neurotropic factor, chemokines, CC chemokine ligand 5 (CCL5) and CXC chemokine lix 5 (CXCL5), versican, tenascin, connective tissue growth factor, stromal cell derived factor-1/ CXC chemokine ligand 12 (SDF-1/CXCL12), and HIF-1 [302]

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BPC-157 has extensive animal data for both gastrointestinal and neurological effects but lacks published large-scale human clinical trials for depression specifically