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MaySeptember in Illinois (Phillips et al., 1999)

Increased GH levels promote tissue repair and muscle regeneration, allowing athletes to recover more quickly and train harder

Dietary supplementation of thiamine down-regulates the expression of mitophagy and endoplasmic reticulum stress-related genes in the rumen epithelium of goats during high-concentrate diet feeding

Reasons vary from side effects to cost and availability

If you have a sensitive stomach, taking them with a light meal is usually the best approach