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47 The 2026 China Patent Cliff: A Global Inflection Point China, the second-largest pharmaceutical market in the world, is facing an imminent patent cliff for semaglutide
GLP-1s cause patients to eat less, with some drugs like Ozempic leading Americans to consume 20% fewer calories, Axios reports
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But the side effects that receive the least attention online are the ones that matter most to anyone considering it: significant lean muscle loss documented by DEXA scanning, dopamine suppression that can flatten mood and drive, and dosing decisions where the difference between 8 mg and 12 mg is roughly 1 percent more fat loss and approximately double the side effects
Even open discussion about any nausea or discomfort can assist physicians in determining whether the dose should remain stable, increase, or decrease
