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For carriers of the effect allele at rs4911414, these habits tend to produce a stronger measurable return because they directly reinforce the signaling environments where this variant has its greatest influence

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Wilson OW, Zou ZH, Bopp M, Bopp CM

In contrast, we found that Sema regulates the expression of mitochondrial regulatory proteins, reduces mitochondrial fission, and restores the expression of mitochondrial respiration-related complex proteins in response to stress