Environmental pollutants, sun exposure, poor diet, chronic stress, smoking, and lack of sleep all contribute to oxidative stress, speeding up skin damage and aging
GGT allows the degradation of GSH and the recycling of its constituent amino acids, such as glutamic acid and cysteine, to generate new GSH (so called -glutamyl cycle)
In 2011, plasma samples from the discovery cohort were collected from 60 unrelated individuals (31 unaffected, 29 konzo affected) in the Kahemba region of the Democratic Republic of the Congo, which is approximately 850 km southeast of the capital of Kinshasa
10.1101/gad.289140.116 284 Van GeldermalsenM.WangQ.NagarajahR.MarshallA
10.1021/bi00824a014 Biochemistry 48 LindstedtG.LindstedtS.MidtvedtT.TofftM
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