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Tang, N., Li, D., Wang, X

Second: the short plasma half-life (~30 min) was insufficient, by the time the fragment circulating in the blood was supposed to act, it had already been metabolized

Activity and safety of enobosarm, a novel, oral, selective androgen receptor modulator, in androgen receptor-positive, oestrogen receptor-positive, and HER2-negative advanced breast cancer (Study G200802): a randomised, open-label, multicentre, multinational, parallel design, phase 2 trial

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they can also slow medication absorption and reduce the drug's effectiveness over time