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A gene expression review analyses how a compound changes the activity of genes across the entire genome

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Synthesis of Glutathione Glutamate-cysteine ligase converts glutamate and cysteine into gamma-glutamylcysteine, and glutathione synthetase adds glycine to form glutathione (GSH)

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Nat Chem Biol 13:9198 Dixon SJ, Winter GE, Musavi LS, Lee ED, Snijder B, Rebsamen M et al (2015) Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death