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Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice
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pMCAO, permanent middle cerebral artery occlusion
in vivo and/or ex vivo / HematologySickle cell diseasePhase I-EnablingBeta-thalassemiaPhase I-Enabling In vivo HSC editingHbF activation / In vivo LNP base editing / HematologySickle cell diseaseResearchBeta-thalassemiaResearch BEAM-302BEAM-302 / SERPINA1 E342K/PiZ mutation correction / In vivo LNP base editing / Liver-targeted genetic diseasesAlpha-1 antitrypsin deficiencyPhase I/IIOngoing Phase 1/2 trial
Osmolality, which is the concentration of solutes in a solution, also plays a role
EGR-1 is a gene that is considered to respond immediately and is potentially involved in the generation of cytokines and growth factors, as well as the early formation of extracellular matrix components like collagen
