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VSMC dysfunction can be defined as the occurrence of excessive proliferation, autophagy, fibrosis, senescence, and phenotypic transformation

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV

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The results were striking: participants receiving the highest 12 mg dose achieved mean weight loss of approximately 24.2% of baseline body weight at week 48, compared to just 2.1% with placebo - representing an astounding 22 percentage point placebo-adjusted treatment effect