This approximately 7-fold longer half-life for ASC37 confirms once-monthly or less dosing frequency
2024 Sep 26
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this is an important achievement as no drugs are available to overcome cisplatin resistance or kill cisplatin-resistant cells
Because treatment was not randomly assigned, the result is an association that strengthens the case for testing metformins impact on healthspan rather than proof that the drug extends life
See a doctor if you have high B12 and High B12 on a blood test doesnt always require action, but certain combinations warrant prompt evaluation: B12 above 1,000 pg/mL without supplementation or injections Unexplained fatigue, weight loss, abdominal pain, or night sweats alongside elevated B12 Abnormal liver function tests (ALT, AST, bilirubin) or kidney markers (creatinine, GFR) on the same panel Abnormal complete blood count (CBC), especially elevated white blood cells, red blood cells, or platelets B12 levels that are rising over serial measurements without a clear dietary or supplement explanation What to do about high B12 levels There is no specific treatment for high vitamin B12 because the B12 level itself is almost never the problem
