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Importantly, localized increases in GLP-1, such as that occur in the gut and portal vein, often have a more profound effect than systemic elevations, emphasizing the therapeutic potential of targeting regional activity rather than relying solely on systemic concentrations

The most definitive indicator is consistent on-target toxicity at therapeutically relevant exposure levels

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Wegovy works by mimicking a hormone called GLP-1, which targets areas of the brain involved in regulating appetite

J Diabetes Investig (2010) 1:823

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily licensed for the management of type 2 diabetes mellitus and, in specific cases, for weight management