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Certain formulations have separate FDA approvals for chronic weight management (Wegovy, Saxenda, Zepbound), with higher-dose semaglutide and tirzepatide capable of producing 1015% weight reduction, while other GLP-1 agents typically yield more modest weight loss

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doi: 10.1002/(SICI)1096-9861(19990111)403:2 3.0.CO;2-5 141 MillerR

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Non-steroidal anti-inflammatory drugs (NSAIDs), statins, glucocorticoids and monoclonal antibodies (e.g., targeting IL-6, TNF-, IL-12/23) have been reported to show moderate anti-depressant capacity in patients with somatic disorders (i.e., rheumatoid arthritis, psoriasis) who also had comorbid symptoms of depression [194, 195]