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Moreover, the phase I study of navoximod combined with the PD-L1 inhibitor, atezolizumab, also showed no significant benefit in the addition of navoximod (Jung et al., 2019)
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Treatment usually begins with a lower dose that gradually increases over weeks (dose titration) to improve tolerability
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Control of sodium excretion by angiotensin II: intrarenal mechanisms and blood pressure regulation