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A recent study has demonstrated that 6-diazo-5-oxo-l-norleucine (DON) facilitates metabolic adaptations in tumor CD8 T cells, exhibiting promising clinical efficacy in ongoing trials [102]

GLP-1 receptor signaling in astrocytes regulates fatty acid oxidation, mitochondrial integrity, and function

N Engl J Med 318:1557-1563, 1988

Reverse-transcription, quantitative PCR (qPCR) RNA was extracted with the RNeasy kit (Qiagen) and reverse transcribed with SuperScript III First-Strand Synthesis SuperMix (Invitrogen)

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Starting at the lower end allows assessment of individual response before increasing if needed