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The current paradigm for skeletal growth holds IGF-1 as a master regulator for skeletal growth and the acquisition of peak bone mass, and much effort has been invested to understand the anabolic pathways downstream of receptor binding

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Proc Natl Acad Sci USA 101:1505215057 Janowiak BE, Griffith OW (2005) Glutathione synthesis in Streptococcus agalactiae

6 Bonemusclefat crosstalk: endocrine functions beyond structural biology For much of the 20th century, bone and skeletal muscle were viewed primarily as structural tissues with limited relevance to systemic metabolic regulation

In high-income countries, diabetes is one of the leading causes of cardiovascular disease, blindness, kidney failure, and lower limb amputation

Nrf2 can bind to the AREs in proteasomal gene promoter, which plays important roles in the degradation of DRP1