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Conflicts of interest Frhbeck G received honoraria from Lilly, Novo Nordisk, Regeneron, AstraZeneca and Boehringer Ingelheim as a member of advisory boards, and honoraria for lectures as a member of the OPEN Spain Initiative

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated from the cerebral venous blood of sleep-deprived rabbits

In a 15 year study, elderly humans treated with intermittent courses of epithalamin (the natural polypeptide source of epithalon) had longer survival rates, better cardiovascular health, fewer pulmonary illnesses, improved carbohydrate and lipid metabolism, and better physical endurance compared to controls [4]

Age-related decline GH secretion declines with age, but pharmacologically increasing GH in otherwise healthy older adults can produce edema, arthralgia, glucose intolerance, and other adverse effects

doi: 10.3389/fimmu.2023.1139589 Received 07 January 2023 Accepted 20 March 2023 Published 18 April 2023 Volume 14 - 2023 Edited by Qun Zhao, Fourth Hospital of Hebei Medical University, China Reviewed by Laiping Zhong, Shanghai Jiao Tong University, China

In addition, several new pathways were created by merging multiple GO gene lists and removing duplicates, as also specified