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OASIS trials: establishing effective doses Phase 2 OASIS 1 findings: Tested multiple dose levels: 0.3mg, 0.6mg, 1.2mg, 2.4mg, 4.5mg weekly Duration: 26 weeks Primary endpoint: Weight loss at each dose Dose-response results: 0.3mg weekly: ~4% body weight loss 0.6mg weekly: ~6% body weight loss 1.2mg weekly: ~8% body weight loss 2.4mg weekly: ~10% body weight loss 4.5mg weekly: ~12% body weight loss Key insight: Clear dose-response relationship

Mice treated with a metalloproteinase that cleaves an IGF-binding protein and decreases IGF-I bioavailability have a 38% longer lifespan and a lower tumor incidence

There are several uses and benefits of the IGF1 LR3, including the boost in metabolic rate, burning fat reserves, and increase in muscle building capacity

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Rotating between sites prevents localized tissue irritation from repeated injection

Associated toxicity includes potential headaches and bleeding problems