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In clinical trials, some participants reported no discernible side effects during the entire first month at the 0.25 mg starting dose

TABLE 2 Core pharmacological mechanisms of glycyrrhizic acid in the Liver

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Some long-term side effects have been reported less often but remain part of ongoing safety discussions

The greatest mean difference of percent body weight change was seen with semaglutide (-11.41%, 95% CI -12.54 to -10.27) and phentermine-topiramate (-7.97%, 95% CI -9.28 to -6.66)

Semaglutide doses are typically administered weekly, starting at a low dose and gradually increasing over time