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The absence of desaturase enzymes necessary for the interconversion between omega-6 and omega-3 PUFAs renders these two families of PUFAs metabolically distinct and potentially opposed in their physiological functions (52)

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In vitro glutathione peroxidase mimicry of ebselen is linked to its oxidation of critical thiols on key cerebral suphydryl proteins - A novel component of its GPx-mimic antioxidant mechanism emerging from its thiol-modulated toxicology and pharmacology

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