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This mechanistic synergy explains why combined use produces results estimated at 30 to 60 percent better than either peptide individually

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Since then, several other medications have joined the lineup, including liraglutide, albiglutide, and dulaglutide [6]

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Overall, more critical nodes are utilised by GLP-1 suggesting more effective communication between the G protein and the peptide-binding sites, relative to the other peptides, which is consistent with a greater allosteric influence of the G protein on GLP-1 affinity