In the past few years, several studies have explored the differences in fecal gut microbiota between MS patients and healthy controls, revealing that gut microbial dysbiosis with both depletion and enrichment of certain gut microbiota in MS patients, as shown in Table 6
This framework integrated evidence through the following streams: (1) Tirzepatide compared to placebo (indirect comparison): In the absence of direct tirzepatide CV outcome placebo-controlled trials, these estimates were derived by bridging direct evidence from SURPASS-CVOT with pooled data from multiple GLP-1RA-placebo trials
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Both show gradual GH elevation over weeks to months
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