in Nature Medicine demonstrated that blocking NNMT in white adipose tissue increased energy expenditure, reduced fat mass, and improved insulin sensitivity in animal models even without changes in diet or activity (Kraus et al., Nature Medicine )
Many peptides sold online or through med spas arent regulated, which means purity, dosage, and safety are all question marks
RGD, ArgGlyAsp
Skipping or shifting doses can increase side effects or disrupt progress
Key Takeaways Eli Lilly is focusing on bimagrumab as a muscle-preserving weight loss solution, addressing a significant gap in the market created by traditional drugs that often lead to muscle loss
For now, and in the context of GLP therapy, it will be important to first better understand the insulin release and response kinetics in normal weight, nondiabetic patients before recommending these meds for a broader population.