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Acknowledgments The authors thank J

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In animal studies, adverse renal pelvic and tubular dilatations, that were not fully reversible, were observed in rats when dapagliflozin (a component of dapagliflozin and saxagliptin) was administered during a period of renal development corresponding to the late second and third trimesters of human pregnancy, at all doses tested

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Early clinical trials in the 2010s demonstrated that semaglutide outperformed existing diabetes medications by improving both glycemic control and body weight