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DarleyUsmar and coworkers have shown that HNE directly modifies Keap1, which allows Nrf2 to avoid degradation and migrate to the nucleus where it can bind to EpRE elements in the promoters of the human GCLC and GCLM genes (Levonen et al., 2004)

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Notably, inhibition of the NLRP3 inflammasome, which is primarily activated in macrophages and microglia (Gold and El Khoury, 2015

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For enhanced results, peptide-infused moisturizers or those with ceramides create an ideal environment for continued peptide activity