In UVB-exposed ICR mice, tuna-derived collagen peptides significantly improved skin moisture and collagen content, which was associated with activation of the TGF-1 pathway and inhibition of MAPK signaling components, including p38, ERK, JNK, and MMP-1 [28]
Over time, I noticed my skin looking fresher and healthier
[DOI] [PubMed] [Google Scholar] 73.Manta B, Bonilla M, Fiestas L, Sturlese M, Salinas G, Bellanda M, Comini MA
Some may notice changes in skin texture and hydration within 12 weeks, but collagen remodeling and deeper changes may take 412 weeks with consistent use
In controlled human dermal studies, 12-week topical application improved measurable collagen density in 70% of subjects
Freezing a reconstituted peptide is generally avoided because the freeze-thaw cycle can damage it