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Scientifically, menopause triggers a sharp drop in estrogen, leading to vulvovaginal atrophy (thinning and drying of tissues), while chronic stress activates the hypothalamic-pituitary-adrenal axis, inhibiting arousal pathways and diverting energy from reproduction to survival.[5][9] Key contributors include: Menopause and perimenopause: Estrogen drop thins vaginal tissues, reduces lubrication, and dampens libido by altering brain chemistry

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But research over the past several years has made one thing clear: The brain plays a central role in how these drugs suppress appetite

The broader wellness industry increasingly frames aging as something that can be managed, optimized, or slowed

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